… conditions of the development of cerebral dysfunctions induced by experimental type-1
DM. … Kuchmerovska, “Diabetes-induced impairments of the exocytosis process and effect of …

… Cardiac overexpression of IGF-1R prevented diabetes-induced cardiac fibrosis and diastolic
dysfunction [27]. In our experiment, compared with the control, HG treatment had no effect …

… - or high-dose fluoride, and P53-knockdown or poly-ADP-ribose polymerase-1 (PARP-1)
inhibition. The levels of PARP-1, P53, poly-ADP-ribose (PAR), apoptosis-inducing factor (AIF), …

… Mitochondria, commonly known as the powerhouse of the cell, play fundamental roles in
maintaining basic cellular functions. Mitochondria dysfunction under stress conditions facilitates …

… dysfunction which contributes to atherosclerosis. Atherosclerosis and dyslipidemia are major
risk factors for cardio-cerebrovascular … 21, 34], suggesting diabetes-induced organ damage. …

… (b) Following ethanol exposure PARP is activated and adds Poly ADP Ribose (PAR)
groups to Pγ. (c) The addition of PAR groups to Pγ prevents it from binding its targets. (For …

… DM is a collection of metabolic disorders characterized by hyperglycaemia resulting from
defects in insulin secretion, action or both owing to disturbance in carbohydrate, fat and protein …

… 84 , 85 caused by fasting, and activates mitochondrial function, and inhibits the activation
of poly[ADP-ribose] polymerase 1 as a DNA damage index 86 , 87 caused by fasting (Figure …

… poly ADP-ribose polymerase (… diabetes induced inflammatory stress in endothelial cells
and neuronal tissue [10], [17]. Objective of the current study is to assess the pathological role of …

… Poly(ADP-ribose) polymerase (PARP) activity was estimated in cardiac and aortic tissue.
HBOT did not alter most of the cardiovascular parameters. PARylation in cardiac and aortic …